Why White Supremacists Are Chugging Milk (and Why Geneticists Are Alarmed)

Hard to combat such wilful ignorance and distortion:

Nowhere on the agenda of the annual meeting of the American Society of Human Genetics, being held in San Diego this week, is a topic plaguing many of its members: the recurring appropriation of the field’s research in the name of white supremacy.

“Sticking your neck out on political issues is difficult,” said Jennifer Wagner, a bioethicist and president of the group’s social issues committee, who had sought to convene a panel on the racist misuse of genetics and found little traction.

But the specter of the field’s ignominious past, which includes support for the American eugenics movement, looms large for many geneticists in light of today’s white identity politics. They also worry about how new tools that are allowing them to home in on the genetic basis of hot-button traits like intelligence will be misconstrued to fit racist ideologies.

In recent months, some scientists have spotted distortions of their own academic papers in far-right internet forums. Others have fielded confused queries about claims of white superiority wrapped in the jargon of human genetics. Misconceptions about how genes factor into America’s stark racial disparities have surfaced in the nation’s increasingly heated arguments over school achievement gaps, immigration and policing.

Instead of long-discounted proxies like skull circumference and family pedigrees, according to experts who track the far-right, today’s proponents of racial hierarchy are making their case by misinterpreting research on the human genome itself. And in debates that have largely been limited to ivory-tower forums, the scientists whose job is to mine humanity’s genetic variations for the collective good are grappling with how to respond.

“Studying human genetic diversity is easier in a society where diversity is clearly valued and celebrated — right now, that is very much on my mind,” said John Novembre, a University of Chicago evolutionary biologist who has taken to closing his visiting seminars to illustrate how one of the field’s textbook examples of natural selection has been adopted for illiberal ends.

One slide Dr. Novembre has folded into his recent talks depicts a group of white nationalists chugging milk at a 2017 gathering to draw attention to a genetic trait known to be more common in white people than others — the ability to digest lactose as adults. It also shows a social media post from an account called “Enter The Milk Zone” with a map lifted from a scientific journal article on the trait’s evolutionary history.

In most of the world, the article explains, the gene that allows for the digestion of lactose switches off after childhood. But with the arrival of the first cattle herders in Europe some 5,000 years ago, a chance mutation that left it turned on provided enough of a nutritional leg up that nearly all of those who survived eventually carried it. In the post, the link is accompanied by a snippet of hate speech urging individuals of African ancestry to leave America. “If you can’t drink milk,” it says in part, “you have to go back.”

In an inconvenient truth for white supremacists, a similar bit of evolution turns out to have occurred among cattle breeders in East Africa. Scientists need to be more aware of the racial lens through which some of their basic findings are being filtered, Dr. Novembre says, and do a better job at pointing out how they can be twisted.

But the white nationalist infatuation with dairy also heightened Dr. Novembre’s concerns about how to handle new evolutionary studies that deal with behavioral traits, such as how long people stay in school.

Anticipating misinterpretations of a recent study on how genes associated with high education attainment, identified in Europeans, varied in different populations around the world, the lead author, Fernando Racimo, created his own “frequently asked questions” document for nonscientists, which he posted on Twitter.

And in a commentary that accompanied the paper in the journal Genetics, Dr. Novembre warned that such research is “wrapped in numerous caveats” that are likely to get lost in translation.

“Great care,” his commentary concludes, “should be taken in communicating results of these studies to general audiences.”

Already, some of those audiences are flaunting DNA ancestry test results indicating exclusively European heritage as though they were racial ID cards. They are celebrating traces of Neanderthal DNA not found in people with only African ancestry. And they are trading messages with the coded term “race realism,” which takes oxygen from the claim that the liberal scientific establishment has obscured the truth about biological racial differences.

Some scientists suggest that engaging with racists would simply lend credibility to obviously specious claims. Many say that they do not study race, in any case: The racial categories used by the United States census correlate only imperfectly with the geographic ancestry groupings of interest to evolutionary geneticists. “Black,” for instance, is a socially defined term that includes many Americans who have a majority of European ancestry.

But as the pace of human population genetics research has accelerated, it has yielded results that, to many nonscientists, appear to challenge the idea of race as a wholly social construction. Genetic ancestry tests advertise “ethnicity estimates” (Senator Elizabeth Warren appealed to the perceived authority of DNA this week to demonstrate her Native American heritage, in response to mocking by President Trump), and some disease-risk genes have turned out to be more common among certain genetic ancestry groups. Doctors use patients’ self-identified race as a proxy for geographic ancestry, because individual readouts of DNA are costly, and though the correlation is imperfect, it exists.

As DNA databases tied to medical records and personal questionnaires have reached a critical mass for individuals of European descent, moreover, so-called polygenic scores that synthesize the hundreds or thousands of genes that contribute to many human traits into a single number are being developed to predict health risks, and in some cases, behavior.

Last summer, researchers developed a score that can roughly predict the level of formal education completed by white Americans by looking at their DNA. And while those scores cannot yet be compared among racial or population groups, the new techniques have prompted some scientists to feel it is the field’s responsibility to head off predictable misrepresentations.

“You have to make a judgment when you have powerful information that can be misused,” said David Reich, a Harvard geneticist who has publicly called on colleagues in a recent book and in a New York Times Op-Ed to more directly address the prospect of identifying genetic differences between populations in socially sensitive traits.

There is no evidence, scientists stress, that environmental and cultural differences will not turn out to be the primary driver of behavioral differences between population groups.

At the same time, the advances in genetic technology have put white supremacists into a kind of anticipatory lather.

“Science is on our side,” crowed Jared Taylor, the founder of the white nationalist group American Renaissance, in a recent video that cites Dr. Reich’s book.

Dr. Reich was among those to decline an invitation to lead a discussion on the topic at the San Diego meeting. “I really wanted to return to research,” he said.

The widespread uncertainty among Americans over what scientists know about genetic differences between racial groups, experts say, has left many flummoxed in the face of white supremacist claims that invoke genetics.

“I was surfing my favorite dumb picture site and I came across a post trying to prove racism with science,” a community college student in Florida wrote to Jun Z. Li, a University of Michigan geneticist whose work has been invoked to buttress racist claims of white intellectual superiority. “I read through the paper myself but I do not have the education or experience to understand and make sure I have a coherent counter argument.”

For white Americans half-inclined to blame nonwhite immigrants or African-Americans for perceived social problems, the veneer of a scientific rationale for white superiority, researchers say, can tip them toward racial resentment. It can be more effective than base appeals to tribalism, especially for the educated demographic the far-right has been targeting.

And while much of current white nationalist rhetoric is framed in terms of preserving a white cultural identity, experts say it relies on a familiar narrative of immutable biological differences. On a YouTube talk show earlier this year, for instance, Gavin McInnes, founder of the Proud Boys, whose appearance set off a brawl outside a Republican club in Manhattan last week, echoed the pet white supremacist theory that the environmental challenges of cold winters explain the supposed higher intelligence of northern Europeans.

Some geneticists have penned blog posts explaining why new genetic tools will not support white nationalist claims that average behavioral differences between groups are immutable. Others — including Dr. Li — have replied directly to individual queries.

And when a blogger at the far-right Unz Review noted that the DNA variations associated with high IQ in a 2017 study of Europeans were at the lowest frequency among Africans, the study’s lead author, Danielle Posthuma, wrote in a published reply that such cross-population comparisons were spurious.

“This,” she wrote, “is a very deep-rooted misunderstanding.”

Many geneticists at the top of their field say they do not have the ability to communicate to a general audience on such a complicated and fraught topic. Some suggest journalists might take up the task. Several declined to speak on the record for this story.

And with much still unknown, some scientists worry that rebutting basic misconceptions without being able to provide definitive answers could do more harm than good.

“There are often many layers of uncertainties in our findings,” said Anna Di Rienzo, a human genetics professor at the University of Chicago. “Being able to communicate that level of uncertainty to a public that often just sees things in black and white is very, very difficult.”

As a step toward changing that, Dr. Di Rienzo has helped organize a meeting of social scientists, geneticists and journalists at Harvard next week to discuss the social implications of the field’s newest tools.

Participants have been promised that the meeting will be restricted to some three-dozen invitees and that any remarks made there will be confidential.

And David L. Nelson, a Baylor College of Medicine geneticist who is president of the human genetics society, says it will not stay completely quiet on the issue, promising a statement later this week.

“There is no genetic evidence to support any racist ideology,” he said.

DNA analysis proves Arabs aren’t entirely Arab

Fascinating genetic analysis showing just how much populations are ‘mixed up’:

Through DNA analysis, the project is answering people’s questions regarding ethnicity, race, and the overall origins of the human population and how we came to populate the Earth.

The Genographic Project lists a group of reference populations, where the typical national of each country is described according to genetic makeup. These are based on hundreds of DNA samples and advanced DNA analysis. Four Arab countries were part of the reference population list.

Here are some surprising discoveries on the genetic makeup of these four Arab nationalities.

Note that the Genographic Project only listed four Arab nationalities in their reference populations, which is the basis of this article. 

Egyptians are only 17% Arabian …

Did you know that native Egyptians’ genetic makeup is 4 percent Jewish diaspora?

Typically, an Egyptian native’s genetic composition is 68 percent North African, 17 percent Arabian, 4 percent Jewish diaspora, and 3 percent from Eastern Africa, Asia Minor and Southern Europe each.

The link to North Africa dates back to when ancient populations first migrated from the continent, which they did through the northeastern route on their way to southwest Asia.

The spread of agriculture led to further migrations from the Fertile Crescent back into Africa as did the spread of Islam from the Arabian peninsula in the 7th century.

Kuwaitis are 7% African …

Native Kuwaitis’ genetic makeup is: 84 percent Arabian, 7 percent from Asia minor, 4 percent North African and 3 percent from East Africa.

Ancient migrants passed through the Middle East when journeying from Africa to Eurasia. Some migrants loved the region so much they decided to stay, developing genetic patterns that were passed down to other generations.

The smaller components from Northern Africa and Eastern Africa may be due to the Arab slave trade, from the 8th to the 19th century.

Lebanese are actually 14% Jewish diaspora …

Lebanese natives’ genetic makeup is the most diverse of all four Arab nationalities.

Typically, a Lebanese natives is 44 percent Arabian, 14 percent Jewish diaspora, 11 percent North African, 10% from Asia minor, 5 percent Southern European and 2 percent Eastern African.

Ancient migrants passed through the Middle East when journeying from Africa to Eurasia. Some of these migrants settled in Lebanon, developing genetic patterns that transcended generations over time.

The Silk Road added genetic patterns from the farther north and east.

Tunisians are only 4% Arabian …

Natives of Tunisia have a pretty interesting genetic composition. They are 88 percent North African, 5 percent Western European, 4 percent Arabian and 2 percent from Western and Central Africa combined.

Historically, Tunisia’s location on the Mediterranean Sea contributed greatly to its broad genetic diversity.

The Arabian component came about with the arrival of agriculture from the Middle East as well as the spread of Islam in the 7th century.

Did you know these non-Arab countries actually have some Arabian genes?

1. Georgia: 5 percent

2. Iran: 56 percent

3. The Luhya people of Kenya: 2 percent

4. Natives of Madagascar: 2 percent

5. The Northern Caucasus (including Dagestanis and Abkhazians): 9 percent

6. Tajikistan (Pamiri mountains): 6 percent

7. Sardinia: 3 percent

8. Southern India: 2 percent

9. Western India: 6 percent

10. Indonesia: 6 percent

11. Ethiopia: 11 percent

12. Ashkenazi Jews (Jews who originated in Eastern Europe): 10 percent

Source: DNA analysis proves Arabs aren’t entirely Arab

Genetic study reveals surprising ancestry of many Americans | Science | AAAS

Reading this summary article, brings to mind Lawrence Hill’s comment in Blood, “who among us is not mixed up.”

But the patterns and variations in the ‘mixing’ reveal and confirm much of history:

In the United States, almost no one can trace their ancestry back to just one place. And for many, the past may hold some surprises, according to a new study. Researchers have found that a significant percentage of African-Americans, European Americans, and Latinos carry ancestry from outside their self-identified ethnicity. The average African-American genome, for example, is nearly a quarter European, and almost 4% of European Americans carry African ancestry.

Until recently, “human population geneticists have tended to ignore the U.S.,” says Joanna Mountain, a geneticist and senior director of research at 23andMe, a company in Mountain View, California, that offers genetic testing. With its long history of migrations from around the world, she says, the country was “considered to be kind of messy in terms of genetics.” But Mountain and her colleagues thought they might have a fighting chance of deciphering Americans’ complex genetic ancestry. Their secret weapon? 23andMe’s huge database of genetic information.

When a person signs up for a 23andMe genetic analysis, they can choose whether to make their data (with any identifying information removed) available for research. At the time when Mountain’s team compiled the database for their study, 23andMe had 500,000 customers, and about 80% of them had given their permission for their information to be used in that way. (Today, the company has about 800,000 customers.) That makes the data set used for the study “an order of magnitude bigger” than those usually used to examine population mixing, says Katarzyna Bryc, a population geneticist at 23andMe and lead author of the new paper.

The team started by looking at the average genetic ancestry of the three largest groups in the United States: European Americans, African-Americans, and Latinos. Those categories are based on how 23andMe customers defined themselves. But as you might expect in a country where different groups of people have been meeting and mixing for hundreds of years, the genetic lines between the groups are quite blurred.

“You see all of those different ancestries in each of these groups,” Bryc explains. The average African-American genome, for example, is 73.2% African, 24% European, and 0.8% Native American, the team reports online today in TheAmerican Journal of Human Genetics. Latinos, meanwhile, carry an average of 18% Native American ancestry, 65.1% European ancestry (mostly from the Iberian Peninsula), and 6.2% African ancestry.

The new study adds an unprecedented level of detail to patterns that had been noticed in previous, more general studies. For example, the 23andMe data reveals that the proportion of different ancestries, even within one self-identified ethnic group, vary significantly by state. Latinos with the highest proportion of African ancestry (about 20%) are from Louisiana, followed by states such as Georgia, North Carolina, New York, and Pennsylvania. In Tennessee and Kentucky, Latinos tend to have high proportions of European ancestry. And in the Southwest, where states share a border with Mexico, Latinos tend to have higher proportions of Native American ancestry.

At least 3.5% of European Americans carry African ancestry, though the averages vary significantly by state. In South Carolina and Louisiana, about 12% of European Americans have at least 1% African ancestry. In Louisiana, too, about 8% of European Americans carry at least 1% Native American ancestry.

In many states, the history of the region is written in the genomes of its current residents. Louisiana, for example, was a trading hub where different populations met and mingled. But sometimes the stories are even more specific. Oklahoma is the state where the most African-Americans have significant Native American ancestry, Bryc notes. That contact can be traced back to the Trail of Tears, when thousands of Native Americans were forcibly relocated to Oklahoma, which was also home to a significant number of black slaves. “You can really see historical events and historical migrations in the genetics,” Bryc says. “We weren’t actually expecting to be able to see that as clearly as we do.”

Another way that history shows up in contemporary genomes is in what researchers call a sex bias. By looking at the kinds of DNA that are passed down only by mothers, they can calculate how many of a person’s ancestors from each population were male and female. In all three populations, they found the same signal: European ancestors tended to be male, while African and Native American ancestors tended to be female. That imbalance reflects the fact that for much of U.S. history, European men were the most aggressive colonizers, Mountain says. This mixing seems to have started almost immediately after the first European colonizers and African slaves arrived in North America. “It suggests that really early U.S. history may have been a time of a lot of mixture,” Bryc says.

The fact that so many people in the United States carry a mix of different ancestries could have important medical implications. Today, doctors often assume that certain genetic variants are associated only with particular populations—think about sickle cell anemia in African-Americans, for example. But a person’s self-identified ethnicity—or the ethnicity her doctor assumes she is—doesn’t “necessarily correspond to [her] underlying genetics,” Bryc says. In a mixed population like the United States, it’s perfectly possible that a European American could carry the sickle cell variant that’s more common in African-Americans. In order for personalized medicine to live up to its potential, she says, doctors need to “consider the person” and her or his ancestry in all its complexity, rather than just falling back on reductive census categories.

The new study is “a beautiful piece of work,” says Andrés Moreno-Estrada, a population geneticist at Stanford University in Palo Alto, California, who has studied genetic diversity in Mexico and wasn’t involved with the new research. “The U.S. has a very particular genetic imprint compared to the rest of the Americas.” The 23andMe study “is one of steps forward in asserting that it’s possible to disentangle that complex scenario.”

Source: Genetic study reveals surprising ancestry of many Americans | Science | AAAS

Hambrick, Ferreira and Henderson: Practice doesn’t necessarily make perfect

Much more nuanced and sophisticated analysis than the pop “triple advantage” theory of Amy Chua’s Tiger Mom’s claim that cultures blessed with ‘triple package’ get ahead in America sparks uproar:

It is therefore crucial to differentiate between the influence of genes on differences in abilities across individuals and the influence of genes on differences across groups. The former has been established beyond any reasonable doubt by decades of research in a number of fields, including psychology, biology and behavioural genetics. There is now an overwhelming scientific consensus that genes contribute to individual differences in abilities. The latter has never been established, and any claim to the contrary is simply false.

Another reason the idea of genetic inequality might make you uncomfortable is because it raises the specter of an anti-meritocratic society in which benefits such as good educations and high-paying jobs go to people who happen to be born with “good” genes. As the technology of genotyping progresses, it is not far-fetched to think that we will all one day have information about our genetic makeup, and that others may have access to this information and use it to make decisions that profoundly affect our lives. However, this concern conflates scientific evidence with how that evidence might be used — which is to say that information about genetic diversity can just as easily be used for good as for ill.

This information could just as easily be used to identify children with the least genetic potential for academic success and channel them into the best schools

Take the example of intelligence, as measured by IQ. We know from many decades of research in behavioural genetics that about half of the variation across people in IQ is due to genes. Among many other outcomes, IQ predicts success in school, and so once we have identified specific genes that account for individual differences in IQ, this information could be used to identify, at birth, children with the greatest genetic potential for academic success and channel them into the best schools. But this information could just as easily be used to identify children with the least genetic potential for academic success and channel them into the best schools. This would allow us to identifying those who are likely to face learning challenges and provide them with the support they might need. Science and policy are two different things, and when we dismiss the former because we assume it will influence the latter in a particular and pernicious way, we limit the good that can be done.

Wouldn’t it be better to just act as if we are equal, evidence to the contrary notwithstanding? That way, no people will be discouraged from chasing their dreams — competing in the Olympics or performing at Carnegie Hall or winning a Nobel Prize.

The answer is no, for two reasons. The first is that failure is costly, both to society and to individuals. Pretending that all people are equal in their abilities will not change the fact that a person with an average IQ is unlikely to become a theoretical physicist, or the fact that a person with a low level of music ability is unlikely to become a concert pianist.

It makes more sense to pay attention to people’s abilities and their likelihood of achieving certain goals, so people can make good decisions about the goals they want to spend their time, money and energy pursuing. Moreover, genes influence not only our abilities, but the environments we create for ourselves and the activities we prefer — a phenomenon known as gene-environment correlation. For example, yet another recent twin study found that there was a genetic influence on practicing music. Pushing someone into a career for which he or she is genetically unsuited will likely not work.

The second reason we should not pretend we are endowed with the same abilities is that doing so perpetuates the myth that is at the root of much inaction in society — the myth that people can help themselves to the same degree if they just try hard enough. You’re not a heart surgeon? That’s your fault for not working hard enough in school! You didn’t make it as a concert pianist? You must not have wanted it that badly. Societal inequality is thus justified on the grounds that anyone who is willing to put in the requisite time and effort can succeed and should be rewarded with a good life, whereas those who struggle to make ends meet are to blame for their situations and should pull themselves up by their own bootstraps.

If we acknowledge that people differ in what they have to contribute, then we have an argument for a society in which all human beings are entitled to a life that includes access to decent housing, health care and education, simply because they are human. Our abilities might not be identical, and our needs surely differ, but our basic human rights are universal.

Hambrick, Ferreira & Henderson: Practice doesn’t necessarily make perfect